Edorium Journal of

Pathology

 
   
Original Article
 
Co-expression of epithelial mesenchymal transition markers NEDD9 and Twist1 in carcinoma of the uterine cervix and their clinical significances
Ola A. Megahed1, Ola A. Harb1, Rham Z. Ahmed2, Safa A. Balata3, Amr AbdAlmohsen Alnemr4
1Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of medical oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Department of clinical oncology and nuclear medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of Gynecology and obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Article ID: 100006P03OM2017
doi:10.5348/P03-2017-6-OA-1

Address correspondence to:
Ola A. Harb MD
PhD, Department of Pathology
Faculty of, 44519 Zagazig University
Zagazig, Egypt

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How to cite this article
Megahed OA, Harb OA, Ahmed RZ, Balata SA, Alnemr AA. Co-expression of epithelial mesenchymal transition markers NEDD9 and Twist1 in carcinoma of the uterine cervix and their clinical significances. Edorium J Pathol 2017;4:1–13.


Abstract

Aims: Aims of our study were to detect NEDD9 and Twist1 co-expressions in carcinoma of the uterine cervix, to correlate such expressions with clinicopathological criteria of the patients and to explore their significances in response to cancer therapy, progression, recurrence and patients’ survival.
Methods: This is a prospective cohort study where we assessed NEDD9 and Twist1 co-expressions by immunohistochemical-technique in fifty paraffin blocks of carcinoma of the uterine cervix, we have followed our patients for three years then we detect relations between markers expressions, pathological criteria, and cancer response to therapy, progression, recurrence and patients’ survival rates.
Results: We detected high expression of NEDD9 in 29 out of 50 (58%) cases and high expression of Twist1 in 23 out of 50 (46%) cases of carcinoma of the uterine cervix. High-expression of both NEDD9 and Twist1 was positively correlated with carcinoma higher grade, advanced FIGO stage, presence of lupus nephritis & distant metastases, higher incidence of carcinoma progression, poor response to therapy, higher rate of recurrence, poor progression free and three year overall survival rates (p < 0.001).
Conclusion: NEDD9 and Twist1 are markers of poor prognosis and can be used as therapeutic targets in carcinoma of the uterine cervix patients.

Keywords: Carcinoma of the uterine cervix, Immunohistochemistry, NEDD9 and Twist1, Prognosis



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Author Contributions:
Ola A. Megahed – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ola A. Harb – Substantial contributions to conception and design, Acquisition of data, Drafting the articles, Revising it critically for important intellectual content, Final approval of the version to be published
Rham Z. Ahmed – Substantial contributions to conception and design, Acquisition of data, Drafting the articles, Revising it critically for important intellectual content, Final approval of the version to be published
Safa A. Balata – Substantial contributions to conception and design, Acquisition of data, Drafting the articles, Revising it critically for important intellectual content; Final approval of the version to be published
Substantial contributions to conception and design, Acquisition of data, Drafting the articles, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2017 Ola A. Megahed et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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